diff --git a/src/usdt.c b/src/usdt.c
index d1524f6..e371093 100644
--- a/src/usdt.c
+++ b/src/usdt.c
@@ -262,6 +262,7 @@ struct usdt_manager {
 	bool has_bpf_cookie;
 	bool has_sema_refcnt;
 	bool has_uprobe_multi;
+	bool has_uprobe_syscall;
 };
 
 struct usdt_manager *usdt_manager_new(struct bpf_object *obj)
@@ -301,6 +302,13 @@ struct usdt_manager *usdt_manager_new(struct bpf_object *obj)
 	 * usdt probes.
 	 */
 	man->has_uprobe_multi = kernel_supports(obj, FEAT_UPROBE_MULTI_LINK);
+
+	/*
+	 * Detect kernel support for uprobe() syscall, it's presence means we can
+	 * take advantage of faster nop5 uprobe handling.
+	 * Added in: 56101b69c919 ("uprobes/x86: Add uprobe syscall to speed up uprobe")
+	 */
+	man->has_uprobe_syscall = kernel_supports(obj, FEAT_UPROBE_SYSCALL);
 	return man;
 }
 
@@ -585,13 +593,34 @@ static int parse_usdt_note(GElf_Nhdr *nhdr, const char *data, size_t name_off,
 
 static int parse_usdt_spec(struct usdt_spec *spec, const struct usdt_note *note, __u64 usdt_cookie);
 
-static int collect_usdt_targets(struct usdt_manager *man, Elf *elf, const char *path, pid_t pid,
-				const char *usdt_provider, const char *usdt_name, __u64 usdt_cookie,
-				struct usdt_target **out_targets, size_t *out_target_cnt)
+#if defined(__x86_64__)
+static bool has_nop_combo(int fd, long off)
+{
+	unsigned char nop_combo[6] = {
+		0x90, 0x0f, 0x1f, 0x44, 0x00, 0x00 /* nop,nop5 */
+	};
+	unsigned char buf[6];
+
+	if (pread(fd, buf, 6, off) != 6)
+		return false;
+	return memcmp(buf, nop_combo, 6) == 0;
+}
+#else
+static bool has_nop_combo(int fd, long off)
+{
+	return false;
+}
+#endif
+
+static int collect_usdt_targets(struct usdt_manager *man, struct elf_fd *elf_fd, const char *path,
+				pid_t pid, const char *usdt_provider, const char *usdt_name,
+				__u64 usdt_cookie, struct usdt_target **out_targets,
+				size_t *out_target_cnt)
 {
 	size_t off, name_off, desc_off, seg_cnt = 0, vma_seg_cnt = 0, target_cnt = 0;
 	struct elf_seg *segs = NULL, *vma_segs = NULL;
 	struct usdt_target *targets = NULL, *target;
+	Elf *elf = elf_fd->elf;
 	long base_addr = 0;
 	Elf_Scn *notes_scn, *base_scn;
 	GElf_Shdr base_shdr, notes_shdr;
@@ -784,6 +813,16 @@ static int collect_usdt_targets(struct usdt_manager *man, Elf *elf, const char *
 		target = &targets[target_cnt];
 		memset(target, 0, sizeof(*target));
 
+		/*
+		 * We have uprobe syscall and usdt with nop,nop5 instructions combo,
+		 * so we can place the uprobe directly on nop5 (+1) and get this probe
+		 * optimized.
+		 */
+		if (man->has_uprobe_syscall && has_nop_combo(elf_fd->fd, usdt_rel_ip)) {
+			usdt_abs_ip++;
+			usdt_rel_ip++;
+		}
+
 		target->abs_ip = usdt_abs_ip;
 		target->rel_ip = usdt_rel_ip;
 		target->sema_off = usdt_sema_off;
@@ -998,7 +1037,7 @@ struct bpf_link *usdt_manager_attach_usdt(struct usdt_manager *man, const struct
 	/* discover USDT in given binary, optionally limiting
 	 * activations to a given PID, if pid > 0
 	 */
-	err = collect_usdt_targets(man, elf_fd.elf, path, pid, usdt_provider, usdt_name,
+	err = collect_usdt_targets(man, &elf_fd, path, pid, usdt_provider, usdt_name,
 				   usdt_cookie, &targets, &target_cnt);
 	if (err <= 0) {
 		err = (err == 0) ? -ENOENT : err;